Tomatensap tegen longemfyseem

Experimenten met muizen hebben aangetoond dat het drinken van veel tomatensap de ontwikkeling van longemfyseem geheel kan voorkomen.

Japanse onderzoekers namen twee muizenrassen, waarvan ze wisten dat de één wél en de ander niet erg gevoelig was voor longziekten. Het gevoelige ras ontwikkelde na acht weken stevig in de tabaksrook te zijn gezet inderdaad emfyseem, de andere soort niet.

Het experiment werd daarna herhaald waarbij het dagelijkse waterrantsoen van de gevoelige soort voor de helft werd vervangen door tomatensap. En het wonder geschiedde: de gevoelige soort liet totaal geen verschijnselen meer zien van longemfyseem.

The paper, “Tomato juice prevents senescence-accelerated mouse P1 strain from developing emphysema induced by chronic exposure to tobacco smoke,” appears in the February issue of the American Journal of Physiology-Lung Cellular and Molecular Physiology,published by the American Physiological Society. Research was performed by Satoshi Kasagi, Kuniaki Seyama, Hiroaki Mori, Sanae Souma, Tadashi Sato, Taeko Akiyoshi and Yoshinosuke Fukuchi at the Juntendo University School of Medicine, Tokyo, and Hiroyuki Suganuma of the Kagome Research Institute, Tochigi, Japan.

FDA questions if effect is from lycopene alone or tomato juice; Japanese concur

The tomato-lycopene link is made even more interesting because late last year the U.S. Food and Drug Administration gave permission for some tomato products to carry highly-qualified labeling claims linking men’s eating tomato products with a reduced incidence of prostate cancer. In reaching its decision, the FDA noted that it’s unclear whether lycopene alone is responsible for the tomato products’ effect.

Similarly, the Japanese researchers noted: “Since mice were given tomato juice instead of pure lycopene preparation, we can not exclude the possibility that other ingredients contained in tomato juice affected the results?.”

Model for further study of pathophysiology and therapeutic intervention

Kuniaki Seyama, coauthor and project leader for the study, said: “The study demonstrated that the SAMP1 strain is a useful model for cigarette-smoke induced emphysema and a valuable tool to explore both pathophysiologic mechanisms and the effect of therapeutic intervention on smoke-induced emphysema.”

Seyama, who is an assistant professor at Juntendo, said the researchers started out to find a good animal model for studying smoking, which is a major health problem in Japan as well as globally. “The basic concept was to establish a mouse model. We looked at the senescence-accelerated mouse (SAM) because it reaches old age after normal development and maturation, and we believe that aging itself is an important component in emphysema.”

Lycopene used because it’s a naturally-occurring oxidant in food

Next, the researchers considered “what was the most important contributing factor in emphysema and we wanted to concentrate on oxidative stress for two reasons,” Seyama said.  “First is because the consequences of oxidative stress during life is considered to be deeply involved in the aging process. And second, tobacco smoke contains lots of oxidants and hence puts oxidative stress on the lungs. Using our mouse model for smoke-induced emphysema, we wanted to intervene in the accumulation process by changing daily lifestyle, especially eating habits, ” Seyama said. Looking for a natural antioxidant in food, “we thought lycopene might be a good candidate,” he added.

However, Seyama (and the AJP-Lung paper Kasagi et al.) cautioned: “We can’t simply accept that these results go beyond the mouse model. They are not so smoothly applied to human beings,” Seyama noted.

Next steps

  • The team would like to test how tomato juice ingestion might affect human patients with COPD (chronic obstructive lung disease), Seyama said.

  • Since overall, the researchers are interested in the mechanisms of nutrients in development of human disease and lifestyle, this study could lead in several other directions, he added.

Tomato juice keeps emphysema from developing in new animal model of degenerative disease

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