Meerookonzin in Trouw

‘Aantal hartinfarcten daalt na rookverbod’, kopt Trouw vandaag op de voorpagina bij een nieuw Italiaans onderzoek waarin zou worden aangetoond dat rookverboden invoeren het aantal hartinfarcten plotklaps vermindert.

Dit is het derde onderzoek op een rij, na de Helena en Pueblo studies, die zijn opgezet volgens een model waarvan de anti-rokenbeweging in het verleden, als het door de tabaksindustrie was uitgebracht, snel had geconcludeerd dat het onder de term ‘junk-science’ zou moeten worden ondergebracht.

Dr. Michael Siegel van de School of Public Health in Boston (met een ervaring van 21 jaar meeroken-onderzoek), houdt deze onderzoeken al enige tijd in de gaten en becommentarieert ze inhoudelijk op zijn blog op wetenschappelijke merites.

En hij laat er methodologisch geen spaan van heel:

  • De toegepaste periode van meting is veel te kort, toevalsfluctuaties worden niet geëlimineerd;

  • Een controlegroep is niet toegepast

  • De gegevens zijn ge-cherry-picked (‘krenten uit de pap’);

  • Er is niet eens een verschil tussen rokers en niet-rokers in het onderzoek meegenomen

En ook van dit onderzoek vraagt hij zich ook af waarom er net dat gebied is genomen. Waarschijnlijk was dit effect hier aan te tonen.

Siegel over de anti-rokenbeweging: “…when the science produces favorable results, it is science; when it produces unfavorable results, it is junk.”

Het gaat bij dit soort onderzoeken om het resultaat, niet om de waarheid. En een Trouw trapt er weer met open ogen in. Maar hoe kan het ook anders met een journalist die lid is van GlobaLink, een wereldwijde organisatie van militante, hard-core anti-rokers?

This is an example of what I would consider to be junk science.

To isolate a five-month period during one year following a smoking ban, compare it to the same five-month period during the previous year, observe a decrease in heart attack admissions, and conclude that the decline was due to the smoking ban is not solid science. It is more on line with what I would term pure speculation.

In fact, this is the precise type of methodology that we in tobacco control have attacked as being unreliable in concluding that smoking bans have resulted in a decline in restaurant sales. Tobacco industry commissioned or funded studies, using the same methodology and finding a decline in restaurant sales associated with smoking bans have been blasted by tobacco control groups as being junk science. There is no reason why we should not view studies using the same methodology in the same way, even though the only real difference is that their findings are supportive of, rather than in opposition to, our agenda.

The biggest problem with this study is that it is impossible to rule out the simplest of alternative hypotheses: that the observed decline in heart attack admissions is simply due to random variation in the data. In other words, it is very possible that the rate of heart attack admissions would have declined in the absence of a smoking ban. It is impossible to tell, and it is impossible to even make a reasonably solid judgment in the absence of any presentation of underlying secular trends over any significant length of time and the absence of any comparison group.

A single point does not indicate a trend, and that is really the fatal flaw of this paper. It is entirely possible that the admission rate simply blipped up a little in 2005 and that in 2006 it will go back down a little. Or that the blip up in 2005 is simply a reflection of an overall trend of decreasing heart attacks during this time period that is not specific to Italy. There’s just no way to know.

If you simply look at the data, you’ll see that concluding that there is a substantial decline in the heart attack rate due to the smoking ban is unfounded. In fact, if you graph out the data for women under 60, it actually appears that the observed decline in admissions in 2005 is due solely to the fact that there was a slight upward blip in 2004.

Based on the heart attack admissions rates among Piedmont women under 60 during the months of February-June from 2001-2003, the observed heart attack admission rate for 2005 should have been 0.16. Instead, it was 0.19. Does this mean that the smoking ban increased the rate of heart attacks among Piedmont women?

The truth is that the observed rate of heart attacks among Piedmont women, ages 60 and younger, during February-June 2005 is exactly the same as it was during the same period in 2003. This doesn’t bode well for a conclusion that there was a substantial decline in heart attacks due to the smoking ban.

The complete absence of a comparison group is another fatal flaw. One simply has no idea what the underlying secular trend in heart attacks was from 2004 to 2005 in the overall region. Thus, it is impossible to attribute any observed decline in the rate to the smoking ban, rather than to a secular trend that would have been observed anyway, even in the absence of the smoking ban.

But the most peculiar aspect of the paper is that the authors felt compelled to stratify their results by age. This is in contrast to any of the previous papers on this topic. So it is somewhat surprising to find this stratification in this paper.

Unfortunately, a closer analysis of the data suggests the reason why the data may have had to be stratified. If one examines the total number of heart attack admissions in Piedmont during the study period, one observes what appears to be an increase in heart attacks, with a 2% increase from February-June 2004 to 2005, the precise comparison period used to draw the study’s major conclusion.

Is it possible that in the original analysis of the data, the paper found this 2% increase, and that the idea of stratifying the data occurred only after the failure to find a decrease in heart attacks when the question was examined in the standard way that it has been looked at in prior research?

The bottom line, that cannot be altered with data manipulation, is that using the same standards of analysis that the authors of the Helena, Saskatoon, and Pueblo studies used, the Piedmont study has demonstrated that the implementation of the smoking ban was associated with a 2% increase in heart attacks. The number of heart attacks from February-June 2005 increased from 3581 to 3655.

The paper argues that the fact that the decline in heart attacks was found only among those under age 60 is evidence that the conclusions are valid. But if you do enough stratification, you’re bound to find some group in which heart attacks declined. To me, this severely weakens, rather than strengthens, the study’s conclusions. The fact that the data had to be manipulated far beyond what has been done in previous research in order to find what appears to be the desired effect greatly weakens the study’s conclusions.

While the paper tries to rationalize its decision to stratify on age based on the supposition that younger people would be more likely to be most affected by a smoking ban, this decision doesn’t jive with the supposed conclusions from Helena and Pueblo. In addition, one could make the argument that if secondhand smoke reductions are going to cause a reduction in heart attacks, this is going to occur among those people with the most severe and brittle coronary artery disease, among whom a slight trigger, such as secondhand smoke, could cause an acute coronary event. But this group is likely to be somewhat older or at least to include older as well as younger individuals.

Another curious quirk of the research, which also comes out of the blue (not done in any of the previous studies on this issue) is the exclusion of most of the data collected in the research. The basic comparison that is made consists only of data from February-June of 2005 versus the same 5 months during 2004. However, the study collected data on heart attacks during the remainder of 2005 and during all the months of the previous 4 years. Why weren’t all of these data used to establish the seasonal and secular trends and random variation in the data and then to examine the complete 2005 heart attack pattern in light of this? Why would one jump to a premature conclusion before even observing the pattern for the entire year?

Perhaps the most interesting aspect of the paper is its conclusion that a reduction in secondhand smoke exposure among nonsmokers caused by the smoking ban could cause an 11% reduction in heart attacks, while the effects of the ban on reducing active smoking could only cause a 0.7% reduction in heart attacks.

As I stated earlier, one would expect the effects of any reductions in active smoking due to smoking bans to have a more substantial effect on heart attacks than any reduction in secondhand smoke exposure (note that active smoking causes far more heart attacks than secondhand smoke). So what the paper has really shown is that one would only expect a very small reduction in heart attacks attributable to a smoking ordinance within a short period of time.

There is another reason why I think one would not expect to see a drastic effect of reduced secondhand smoke exposure on heart attacks within a several month period. In order to expect such an effect, one would have to postulate that secondhand smoke triggers acute cardiac events in persons with severe coronary artery disease, who are basically time bombs waiting to go off. In other words, the slightest insult to the system is capable of triggering a heart attack.

Well, if you eliminate secondhand smoke exposure, these people are still going to be susceptible to any other trigger. Eating a high-fat meal causes endothelial dysfunction, and might also trigger a cardiac event. So it is not clear that simply eliminating secondhand smoke exposure would prevent these individuals from suffering heart attacks.

It seems to me that we’ve set ourselves up for a giant failure. We’ve now led to the world to expect that we’re going to be able to demonstrate drastic and immediate reductions in heart attacks following smoking bans. But I don’t think such an effect is plausible. So when more carefully conducted studies, with longer follow-up periods, are finally conducted, they are most likely not going to find such effects. Then, instead of simply reasoning that one wouldn’t expect dramatic effects, the public is going to conclude that the whole thing was a big hoax. By making this the cornerstone for our arguments in support of smoking bans, when this thing is shown to be untrue, the whole building might come crumbling down.

Although I’ve been quite harshly critical of the conclusions of the Helena and Pueblo studies, the Piedmont study is by far the weakest of the three. There is no comparison group, it fails to analyze all the available data, it is forced to stratify the data in order to find an effect, and it truly uses only one data point following the implementation of the smoking ban.

The study actually finds an increase in heart attacks from 3581 to 3655, a 2% increase, that is associated with the implementation of the smoking ban. Thus, in some ways, this study actually disproves the conclusions from Helena and Pueblo. Yet the data are manipulated in a way that tries to make it appear that there was a dramatic decline in heart attacks. Even accepting the data manipulation, this conclusion is completely unfounded.

The Piedmont study is an example of junk science and as much as we in the tobacco control field would like to accept its conclusions, doing so is going to make us hypocrites, destroying our credibility.

Anti-smoking groups and researchers need to discredit this study’s conclusions in order to make it clear that we have some scientific integrity and that as much as we would like to see dramatic effects from our interventions, we will not disseminate information to the public to support our agenda unless it is based upon solid science.

Piedmont Italy Study Becomes the Latest in a String of Junk Science Papers on Effects of Smoking Bans on Heart Attack Admissions
Piedmont Study Methodology is Similar to Studies Showing Adverse Economic Effects of Smoking Bans; Junk Science Cuts Both Ways

Aantal hartinfarcten daalt na rookverbod (Trouw)

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  • "Es ist schwieriger, eine vorgefaßte Meinung zu zertrümmern als ein Atom."
    (Het is moeilijker een vooroordeel aan flarden te schieten dan een atoom.)
    Albert Einstein

  • "Als je alles zou laten dat slecht is voor je gezondheid, dan ging je kapot"
    Anonieme arts

  • "The effects of other people smoking in my presence is so small it doesn't worry me."
    Sir Richard Doll, 2001

  • "Een leugen wordt de waarheid als hij maar vaak genoeg wordt herhaald"
    Joseph Goebbels, Minister van Propaganda, Nazi Duitsland

  • "First they ignore you, then they laugh at you, then they fight you, then you win."
    Mahatma Gandhi

  • "There''s no such thing as perfect air. If there was, God wouldn''t have put bristles in our noses"
    Coun. Bill Clement

  • "Better a smoking freedom than a non-smoking tyranny"
    Antonio Martino, Italiaanse Minister van Defensie

  • "If smoking cigars is not permitted in heaven, I won't go."
    Mark Twain

  • I've alllllllways said that asking smokers "do you want to quit?" and reporting the results of that question, as is, is horribly misleading. It's a TWO part question. After asking if one wants to quit it must be followed up with "Why?" Ask why and the majority of the answers will be "because I'm supposed to" (victims of guilt and propaganda), not "because I want to."
    Audrey Silk, NYCCLASH